![]() We included 17 studies in the review with a total of 1193 participants. We included randomised trials (gold-standard trials for evaluating the effectiveness of treatments where participants are randomly assigned to one of two or more treatments) published before January 2022. placebo, or dummy treatment) or other types of medications. We investigated whether different types of medications are effective in reducing gambling symptoms compared to no treatment (i.e. A range of medications are used to treat people with gambling problems, but there are few high-quality reviews of the research evidence to guide which ones should be used in practice. We conclude that pathological gambling may be a syndrome that includes features of affect instability, impaired cognitive control of impulses, and addiction.Gambling problems can lead to severe consequences for gamblers, their family members and friends, and the community. Other classes of medications such as opioid antagonists, mood stabilizers, and other antidepressants, have also shown promise in the treatment of pathological gambling. Speculation that pathological gambling may be related to a dimension of impulsivity and obsessive-compulsive disorders prompted trials of medications shown to be efficacious with obsessive-compulsive disorder, such as the selective serotonin reuptake inhibitors. The rationale for pharmacological approaches during those early stages of this form of intervention was based on attempts to simply block reinforcing affective “thrill” components inherent in gambling or on clinical judgment that drew analogies between the manifestations of repetitive gambling behavior and compulsions. ![]() This article provides a brief overview of the development of pharmacological approaches in the treatment of problem or pathological gambling. The results suggest that extended release carbamazepine may be effective in the treatment of PG. Several patients were dropped because of adverse experiences. Four subjects (50%) abstained from gambling during their final month of study participation. Seven of the eight subjects with post-baseline assessment (88%) were considered responders (i.e., achieved & amp amp amp amp amp amp amp amp amp amp amp amp amp quot much& amp amp amp amp amp amp amp amp amp amp amp amp amp quot or & amp amp amp amp amp amp amp amp amp amp amp amp amp quot very much& amp amp amp amp amp amp amp amp amp amp amp amp amp quot improvement on the CGI). Significant improvement was found on the YBOCS-PG (P& amp amp amp amp amp amp amp amp amp amp amp amp amp lt. Eight subjects (6 men, 2 women) had at least one post-baseline visit, and five subjects (63%) completed the protocol. The primary efficacy measure was the Yale-Brown Obsessive-Compulsive Scale modified for PG (YBOCS-PG). ![]() Subjects were evaluated at baseline and at one week intervals during a four week titration period, and every two weeks thereafter for assessment of gambling behavior, mood, and adverse experiences. ![]() Non-depressed outpatients with DSM-IV PG received flexibly dosed extended release carbamazepine in a prospective 10-week open-label trial following a two-week observation period. ![]() The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG). ![]()
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